Mount Brydges has a small commercial "downtown" featuring mostly local businesses and shops. Local agriculture includes maize, tobacco and wheat. The soil composition of the region is largely sandy (a phenomenon referred to locally as the "Caradoc Sand Plains") as a result of deposits created on the bottom of the glacial Lake Whittlesey which covered the area approximately 13,000 years ago.
The village came into existence as a result of the construction of the western division of the Great Western Railroad from City of London, Ontario to Windsor, Ontario, at the point where it crossed the existing road from Delaware, Ontario to Strathroy. This crossing happened to be at the point of greatest elevation on this division, the railroad having just climbed out of the valley of the Thames River from London. The station was named for Charles John Brydges the Managing Director of the Railroad. Contrary to a previous suggestion the name had nothing to do with an early settler named Mount, who had left the area more than two decades earlier.